bicozamycin Property

Melting point:

188-191° (dec); mp 187-189° (dec) (Imanaka); mp 166-170° (Nakatsuka et al.)

alpha 

D23 +63.5° (methanol)

Boiling point:

786.6±60.0 °C(Predicted)

Density 

1.57±0.1 g/cm3(Predicted)

pka

9.85±0.60(Predicted)

Safety

Toxicity

LD50 in mice: >4 g/kg (Williams, Durham)

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H300Fatal if swallowed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

P321Specific treatment (see … on this label).

P330Rinse mouth.

P405Store locked up.

P501Dispose of contents/container to..…

bicozamycin Chemical Properties,Usage,Production

Uses

Bicyclomycin is a polar metabolite first isolated from Streptomyces sapporonensis in 1972. The selective Gram negative profile of bicyclomycin is rare among Streptomyces metabolites. The primary site of action for bicyclomycin is thought to be the rho transcription termination factor.

Definition

ChEBI: A commercially important azabicyclic antibiotic obtained from Streptomyces sapporonensis. It inhibits the Rho protein of E. coli.

Origin

Bicozamycin, formerly called bicyclomycin, was found independently in 1972, in the cul ture broth of Streptomyces sapporonensisbyFu jisawa Pharmaceuticals Industries and in that of S. aizuensis by Miyamura et al. of Ni igata University.

Biological Activity

Bicozamycin has a unique bicyclic structure and shows activity against Kleb siella, Salmonella, and Shigella but noneagainst other gram-negative bacteria or gram-positive microorganisms.

Safety

Bicozamycin is not absorbed orally and showsverylowtoxicity;nomicedied following its intravenous injection at a dose as high as two grams per kilogram.